Simultaneous analysis of hepatotoxic pyrrolizidine alkaloids and N-oxides in comfrey root by LC-ion trap mass spectrometry

文献信息

发布日期 2004-01-08

DOI 10.1039/B311030C

影响因子 4.616

作者

Jorgelina C. A. Wuilloud, Samuel R. Gratz, Bryan M. Gamble, Karen A. Wolnik

查看原文

摘要

The purpose of the current study was to develop a LC-MSn method for the analysis of pyrrolizidine alkaloids (PAs) in comfrey. Published data presents an extensive list of PAs and their N-oxides present in comfrey. However, standards are not commercially available for any of the PAs typically present in comfrey. Those PAs that are not stereoisomers were readily resolved on a C18 column using a water–acetonitrile gradient as the mobile phase. The use of a selective technique, LC-MS/MS, allowed us to identify groups of PAs and their N-oxides, as well as identify the number of PAs present in each group, including those that were not completely resolved chromatographically.

期刊推荐

Green Chemistry

Coloration Technology

Journal of Medical Biochemistry

Mini-Reviews in Medicinal Chemistry

European Journal of Organic Chemistry

Environmental Toxicology and Pharmacology

Photochemical & Photobiological Sciences

Lab on a Chip

Foundations of Chemistry

Nature Reviews Drug Discovery

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Simultaneous analysis of hepatotoxic pyrrolizidine alkaloids and N-oxides in comfrey root by LC-ion trap mass spectrometry

文献信息

期刊推荐

相关文献

Polycarbazole-SEBS-crosslinked AEMs based on two spacer polymers for high-performance AEMWE

Synergistic carrier and phonon transport advance Ag dynamically-doped n-type PbTe thermoelectrics via Mn alloying

Fast redox conversion in lithium–sulfur batteries enabled by Cu-doped W18O49 with abundant oxygen defects

How to make membrane distillation greener: a review of environmentally friendly and sustainable aspects

Direct measurement of the hydrogen adsorption entropy on shape-controlled Pt nanoparticles using electrochemical microcalorimetry

Inducing local charge polarization by constructing isomeric covalent organic frameworks with different orientations of imine bonds for enhancing photocatalytic hydrogen evolution

Correction: Achieving highly efficient CO2 to CO electroreduction exceeding 300 mA cm−2 with single-atom nickel electrocatalysts

Front cover

Aromatic polyaroxydiazole pseudocapacitive anode materials with tunable electrochemical performance through side group engineering

Back cover

您可能还喜欢

如何处理含有顺-二(2,2'-联吡啶)二氯化钌(II)二水合物(CAS号：67776-38-9)的废料？

4-amino-2-bromo-3-iodopyridine(CAS号：1300750-77-9)的市场或研究趋势如何？

4-乙酰基氨基-2-氨基-苯甲酸(CAS号：43134-76-5)的市场或研究趋势如何？

庚a氟-1-(1-碘-1,2,2,2-四氟乙氧基)丙烷(CAS号：107432-46-2)的市场或研究趋势如何？

在合成中是否有Propargyl-PEG13-bromide(CAS号：2055105-25-2)的替代品？

2-氨基-6-甲氧基嘌呤(CAS号：20535-83-5)安全吗？

2-甲基-3-溴苯乙酸乙酯(CAS号：1261862-72-9)适用哪些法规指南？

4,4-二甲基吡咯烷-3-羧酸盐酸盐(CAS号：1351343-41-3)应用于哪些行业？

处理5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside(CAS号：149998-39-0)时应注意哪些实验室安全事项？

7-甲基-1,2,3,4-四氢-吖啶-9-甲酸(CAS号：345621-27-4)的市场或研究趋势如何？

来源期刊

Analyst

推荐化合物

4-Nitrophenyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-isoleucinate

4-bromobenzenesulfinic Acid

L-Threonine, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide, acetate (salt) (9CI)

2-Methyl-5-(trifluoromethyl)pyridine

2,5-Dibromothiophene-3-carbaldehyde

推荐供应商