Screening flavonoidmetabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS
文献信息
发布日期
2004-10-26
DOI
10.1039/B412577K
影响因子
4.616
作者
Junmei Zhang, Jennifer S. Brodbelt
查看原文
摘要
The main flavonoids in grapefruit juice, naringin and narirutin, were quantified by LC-MS with structural differentiation by LC-MS/MS. After human consumption of grapefruit juice, urine samples were collected for 24 hours and screened for flavonoid metabolites by LC-MS. The metabolite structures (glucuronides, sulfates, and glucuronide sulfates) were then confirmed via their unique fragmentation patterns by LC-MS/MS. To further verify the identity of the common aglycon (naringenin) shared by the metabolites, enzymatic hydrolysis was performed and the resulting products were analyzed. This work demonstrates that LC-MS and LC-MS/MS techniques can be used for fast metabolite screening without extensive sample preparation.
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