Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR

文献信息

发布日期 2006-09-14
DOI 10.1039/B610007D
影响因子 6.222
作者

Ziwei Xiao, Na Zhang, Yiqing Lin, Graham B. Jones, Irving H. Goldberg


查看原文

摘要

Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.

相关文献

Pore size effects in the pyrolysis of 1,3-diphenylpropane confined in mesoporous silicas

Michelle K. Kidder, Phillip F. Britt, Zongtao Zhang, Sheng Dai, A. C. Buchanan, III

2003-10-15 Communication

DOI: 10.1039/B310405B

Free energy of adsorption of water and calcium on the {10 4} calcite surface

Sebastien Kerisit, Stephen C. Parker

2003-12-02 Communication

DOI: 10.1039/B311928A

Mixed halo/hydroxy carborane anions: thermally stable platforms for hydronium ion isolation

Daniel J. Stasko, Kevin J. Perzynski, Mark A. Wasil

2004-02-16 Communication

DOI: 10.1039/B314475E

Confined organization of Au nanocrystals in glycolipidnanotube hollow cylinders

Bo Yang, Shoko Kamiya, Kaname Yoshida

2004-02-09 Communication

DOI: 10.1039/B313100A

The synthesis of a di-N-heterocyclic carbene-amido complex of palladium(ii)

Richard E. Douthwaite, Jennifer Houghton, Benson M. Kariuki

2004-02-13 Communication

DOI: 10.1039/B314814A

First three examples of taxane-derived di-propellanes in Taxus canadensis needles

Qing Wen Shi, Françoise Sauriol, Alain Lesimple, Lolita O. Zamir

2004-02-04 Communication

DOI: 10.1039/B316051C

Continuous synthesis of CdSe–ZnS composite nanoparticles in a microfluidic reactor

Hongzhi Wang, Xianying Li, Masato Uehara, Yoshiko Yamaguchi, Hiroyuki Nakamura, Masaya Miyazaki, Hazime Shimizu, Hideaki Maeda

2003-12-02 Communication

DOI: 10.1039/B310644F

Inherent helicity in an extended tris-bipyridyl molecular cage

David F. Perkins, Leonard F. Lindoy, George V. Meehan, Peter Turner

2003-11-20 Communication

DOI: 10.1039/B312716H

Preparation of highly accessible mordenite coatings on ceramic monoliths at loadings exceeding 50% by weight

M. A. Ulla, E. Miro, R. Mallada, J. Coronas, J. Santamaría

2004-01-29 Communication

DOI: 10.1039/B315386J

Nickel-catalyzed highly chemoselective cocyclotrimerization of arynes with allenes: a novel method for 10-methylene-9,10-dihydrophenanthrenes

Jen-Chieh Hsieh, Dinesh Kumar Rayabarapu, Chien-Hong Cheng

2004-02-04 Communication

DOI: 10.1039/B315795D

您可能还喜欢

化合物问答

如何处理含有顺-二(2,2'-联吡啶)二氯化钌(II)二水合物(CAS号:67776-38-9)的废料?

处理含有该化合物的废料时,应先收集并分类,然后根据其危险特性选择合适的处理方法。推荐采用焚烧或由专业机构进行安全处理,以确保符合环保法规的要求。处理过程中应佩戴...

67776-38-93-{[(2R,3R,4S,5R,6R)...
化合物问答

4-amino-2-bromo-3-iodopyridine(CAS号:1300750-77-9)的市场或研究趋势如何?

4-氨基-2-溴-3-碘吡啶主要应用于药物合成和研究领域,尤其是在抗病毒和抗癌药物的研发中。随着新型药物的需求增加,该化合物的研究趋势较好。市场方面,由于其特殊...

1300750-77-92-bromo-3-iodopyridi...
化合物问答

4-乙酰基氨基-2-氨基-苯甲酸(CAS号:43134-76-5)的市场或研究趋势如何?

当前,4-乙酰基氨基-2-氨基-苯甲酸(CAS号:43134-76-5)在医药和化工领域有一定的应用。随着药物研发的进展,该化合物在新型药物设计中的应用可能增加...

43134-76-54-Acetamido-2-aminob...
化合物问答

庚a氟-1-(1-碘-1,2,2,2-四氟乙氧基)丙烷(CAS号:107432-46-2)的市场或研究趋势如何?

该化合物目前主要用于特定的工业应用,如氟聚合物的合成。市场趋势显示,由于其独特的结构和性能,未来可能在新型氟材料和特种化学品领域有更多的应用。研究趋势方面,主要...

107432-46-21,1,1,2,2,3,3-Heptaf...
化合物问答

在合成中是否有Propargyl-PEG13-bromide(CAS号:2055105-25-2)的替代品?

可以考虑使用1,3-丁二烯-1-炔-3-基-聚乙二醇-13-溴化物作为Propargyl-PEG13-bromide的替代品,因为两者在结构上相似,均可用于合成...

2055105-25-2Propargyl-peg13-brom...
化合物问答

2-氨基-6-甲氧基嘌呤(CAS号:20535-83-5)安全吗?

2-氨基-6-甲氧基嘌呤在正常使用条件下相对安全,但在操作时仍需注意防护措施,如佩戴手套和护目镜,避免吸入或接触皮肤和眼睛。

20535-83-56-Methoxy-7H-purin-2...
化合物问答

2-甲基-3-溴苯乙酸乙酯(CAS号:1261862-72-9)适用哪些法规指南?

该化合物根据其化学性质和潜在危害,可能适用于GHS(全球化学品统一分类和标签制度)的分类标准。具体分类需依据其毒性和燃烧危险性进行评估。此外,欧洲化学品管理局(...

1261862-72-9Ethyl (3-bromo-2-met...
化合物问答

4,4-二甲基吡咯烷-3-羧酸盐酸盐(CAS号:1351343-41-3)应用于哪些行业?

4,4-二甲基吡咯烷-3-羧酸盐酸盐在医药、聚合物和传感器领域有应用。在医药领域,它可以作为某些药物的中间体;在聚合物领域,它可用作某些聚合物的稳定剂;在传感器...

1351343-41-34,4-Dimethyl-3-pyrro...
化合物问答

处理5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside(CAS号:149998-39-0)时应注意哪些实验室安全事项?

处理该化合物时应注意使用个人防护装备(如手套、护目镜和实验服),在通风橱中操作。避免直接接触皮肤和吸入,泄漏时应立即清理并使用适当的吸收材料。参考安全数据表(S...

149998-39-05-Hydroxy-7-methoxy-...
化合物问答

7-甲基-1,2,3,4-四氢-吖啶-9-甲酸(CAS号:345621-27-4)的市场或研究趋势如何?

该化合物在医药研究中具有潜在应用价值,特别是在抗癌药物研发方面。随着研究的深入,对其合成方法的优化和生物活性的进一步探索将成为研究热点。

345621-27-47-Methyl-1,2,3,4-tet...

来源期刊

Chemical Communications

Chemical Communications
CiteScore: 8.6
自引率: 4.7%
年发文量: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。