Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC
文献信息
发布日期
2008-02-05
DOI
10.1039/B719353J
影响因子
6.222
作者
Suresh R. Chawrai, Neil R. Williamson, George P. C. Salmond, Finian J. Leeper
查看原文
摘要
Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, PigC, has a relaxed substrate-specificity.
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来源期刊
Chemical Communications
CiteScore:
8.6
自引率:
4.7%
年发文量:
2458
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