SERRS coded nanoparticles for biomolecular labelling with wavelength-tunable discrimination‡

文献信息

发布日期 2008-12-08

DOI 10.1039/B813821D

影响因子 4.616

作者

Fiona McKenzie, Andrew Ingram, Robert Stokes, Duncan Graham

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摘要

The preparation and use of tri-functional linkers for surface complexation to both gold and silver nanoparticles is reported. These molecules confer excellent stability towards nanoparticles ensuring particle monodispersity in biological buffers, and also incorporate dyes to allow use of the functionalised nanoparticles as SERRS reporters. Biomolecule conjugation and quantitation has been illustrated using Alexafluor 680 labelled streptavidin. Variation of the chromophore has been introduced, which allows for exquisite control of the SERRS by manipulation of laser wavelength. This demonstrates the potential of SERRS functionalised nanoparticles for multiple, simultaneous monitoring of excitation events, an area of research where the capability of molecular fluorophores and quantum dots is limited.

期刊推荐

Studies in Conservation

Drug and Chemical Toxicology

Annual Review of Public Health

Journal of Natural Products

Organic Geochemistry

Journal of Dispersion Science and Technology

Dyes and Pigments

Synthetic Communications

Applied Surface Science

Crystal Research and Technology

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

SERRS coded nanoparticles for biomolecular labelling with wavelength-tunable discrimination‡

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