Stereoselective Reformatskii–Claisen rearrangement: synthesis of 2′,3′-dideoxy-6′,6′-difluoro-2′-thionucleosides
文献信息
发布日期
2009-01-26
DOI
10.1039/B819289H
影响因子
6.222
作者
Feng Zheng, Xingang Zhang, Feng-Ling Qing
查看原文
摘要
A new approach for the stereoselective synthesis of 2′,3′-dideoxy-6′,6′-difluoro-2′-thionucleosides, analogues of highly bioactive L-OddC and 3TC, has been developed viaTMSCl/pyridine induced stereoselective Reformatskii–Claisen rearrangement of secondary allyl chlorodifluoroacetate and then a regioselective Pummerer reaction to introduce bases.
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来源期刊
Chemical Communications
CiteScore:
8.6
自引率:
4.7%
年发文量:
2458
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