Phenotypic heterogeneity within microbial populations at the single-cell level investigated by confocal Raman microspectroscopy

文献信息

发布日期 2009-03-25

DOI 10.1039/B822574E

影响因子 4.616

作者

Antje Hermelink, Angelika Brauer, Peter Lasch, Dieter Naumann

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摘要

Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic heterogeneity that is considered to bolster the fitness of the whole population. Heterogeneity on the single-cell level is typically masked in conventional studies of microbial populations, which rely on data averaged across thousands or millions of cells in a sample. Here we introduce confocal Raman microspectroscopy as a method for investigating and illustrating the spatial heterogeneity of microbial cell populations. By the use of three different test organisms as model systems, we show pronounced cellular heterogeneity even in colonies cultivated under laboratory conditions.

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Herald of the Russian Academy of Sciences

Chinese Journal of Chemistry

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Main Group Chemistry

Journal of the Indian Institute of Science

Critical Reviews in Solid State and Materials Sciences

Journal of Chemical Sciences

Polycyclic Aromatic Compounds

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Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Phenotypic heterogeneity within microbial populations at the single-cell level investigated by confocal Raman microspectroscopy

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