Application of REDORNMR in natural product chemistry
文献信息
发布日期
2009-08-04
DOI
10.1039/B910230B
影响因子
6.222
作者
Shigeru Matsuoka, Masayuki Inoue
查看原文
摘要
Many natural products have molecular targets that are non-crystalline and insoluble biological matrices, such as proteins embedded in lipid membrane, cell membranes, and cell walls. To understand the action mechanisms, it is essential to determine the binding structure with atomic-level resolution. For structural studies of biological solids, high resolution distance measurements using solid-state nuclear magnetic resonance (NMR) are indispensable techniques, of which rotational-echo double-resonance (REDOR) is one of the most widely used methods. This feature article introduces the basic concepts of REDORNMR and its application to the structural study of natural products in biological matrices.
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来源期刊
Chemical Communications
CiteScore:
8.6
自引率:
4.7%
年发文量:
2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
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