Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

文献信息

发布日期 2010-08-06

DOI 10.1039/C0PY00117A

影响因子 5.582

作者

Mathurin Grogna, Rudi Cloots, André Luxen, Christine Jérôme, Catherine Passirani, Nolwenn Lautram, Jean-F. Desreux, Christophe Detrembleur

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摘要

New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents.

期刊推荐

Synlett

Advanced Materials

Construction and Building Materials

Advances in Cement Research

Applied Composite Materials

Advanced Composite Materials

Composite Interfaces

Journal of Physical Organic Chemistry

Heterocyclic Communications

Chemistry of Materials

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

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