Oligoagarose-g-polycaprolactone loaded nanoparticles for drug delivery applications
文献信息
发布日期
2010-10-29
DOI
10.1039/C0PY00311E
影响因子
5.582
作者
Archana Bhaw-Luximon, Laila Musharat Meeram, Yeshma Jugdawa, William Helbert, Dhanjay Jhurry
查看原文
摘要
Well-defined oligoagarose-g-polycaprolactone copolymers of varying PCL chain lengths have been synthesised using protection/deprotection chemistry. The graft copolymers showed amphiphilic behaviour with spherical micelles in the size range 10 to 20 nm. Ketoprofen was loaded into the core of the micelles. The drug loading efficiency was shown to increase with the length of the hydrophobic PCL chain: 2% for PCL10 and 5.5% for PCL15. Sustained drug release was observed over a period of 72 h and was faster with shorter PCL chains.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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