Measuring a diffusion coefficient by single-particle tracking: statistical analysis of experimental mean squared displacement curves

文献信息

发布日期 2012-11-14
DOI 10.1039/C2CP43433D
影响因子 3.676
作者

Dominique Ernst, Jürgen Köhler


查看原文

摘要

We provide experimental results on the accuracy of diffusion coefficients obtained by a mean squared displacement (MSD) analysis of single-particle trajectories. We have recorded very long trajectories comprising more than 1.5 × 105 data points and decomposed these long trajectories into shorter segments providing us with ensembles of trajectories of variable lengths. This enabled a statistical analysis of the resulting MSD curves as a function of the lengths of the segments. We find that the relative error of the diffusion coefficient can be minimized by taking an optimum number of points into account for fitting the MSD curves, and that this optimum does not depend on the segment length. Yet, the magnitude of the relative error for the diffusion coefficient does, and achieving an accuracy in the order of 10% requires the recording of trajectories with about 1000 data points. Finally, we compare our results with theoretical predictions and find very good qualitative and quantitative agreement between experiment and theory.

相关文献

Physically cross-linked organo-hydrogels for friction interfaces in joint replacements: design, evaluation and potential clinical applications

Zheng Li, Jia Wan, Wanbo Zhu, Yingjie Wang, Yuan Chen, Baoliang Lu, Junchen Zhu, Chen Zhu, Xianzuo Zhang

2023-11-16 Paper

DOI: 10.1039/D3TB01830J

Back cover

2023-11-22 Cover

DOI: 10.1039/D3TB90221H

Highly efficient degradation of tetracycline by activated peroxymonosulfate over MoS2/ZnO heterostructure nanocomposites

Lili Wang, Yuyang Zhou, Haixiang Wang, Qiaoli Lu, Jinmei Wang, Dawei Gao

2023-11-10 Paper

DOI: 10.1039/D3NJ04717B

Rectal delivery of 89Zr-labeled infliximab-loaded nanoparticles enables PET imaging-guided localized therapy of inflammatory bowel disease

Yeli Fan, Xinyu Wang, Ge Yan, Hongfang Gao, Min Yang

2023-11-14 Communication

DOI: 10.1039/D3TB02128A

Calixarene-based cryoprotectants for ice recrystallization inhibition and cell cryopreservation

Bing Hu, Juan-Juan Li, Yan-Bin Ren, Tian-Xing Zhang, Li-Bin Chen, Xiao-Liu Li, Ke-Rang Wang

2023-11-20 Communication

DOI: 10.1039/D3TB02432F

A fuel-initiated DNA molecular machine for microRNA detection in serum via poly-adenine-mediated spherical nucleic acids

Xiaoqing Yi, Zhiwei Shang, Xianliang Nong, Fan Xia

2023-11-01 Paper

DOI: 10.1039/D3TB02361C

Contents list

2023-12-06 Front/Back Matter

DOI: 10.1039/D3TB90229C

Belinostat loaded lipid–polymer hybrid nanoparticulate delivery system for breast cancer: improved pharmacokinetics and biodistribution in a tumor model

Kommera Sai Pradyuth, Shubham A. Salunkhe, Arihant Kumar Singh, Deepak Chitkara, Anupama Mittal

2023-10-27 Paper

DOI: 10.1039/D3TB01317K

Construction of a polymer-based fluorescent probe with dual responsive sites for monitoring changes of lysosomal viscosity

Faqi Yu, Ruiyang Fan, Yansheng Zhao, Yijun Chen, Xiuqi Kong

2023-12-05 Paper

DOI: 10.1039/D3TB02232C

Self-driven immune checkpoint blockade and spatiotemporal-sensitive immune response monitoring in acute myeloid leukemia using an all-in-one turn-on bionanoprobe

Honglian Wu, Tianci Wang, Yuting Wang, Sixi Liu, Feiqiu Wen, Gerile Oudeng, Mo Yang

2023-10-17 Paper

DOI: 10.1039/D3TB01553J

您可能还喜欢

化合物问答

(3-氨苯基)环丙基甲酮(CAS号:162174-75-6)的主要用途是什么?

(3-氨苯基)环丙基甲酮主要用于合成化学中间体,特别是在药物化学领域作为原料。它还可以用于有机合成反应中,作为催化剂或反应物。

162174-75-6(3-Aminophenyl)(cycl...
化合物问答

如何储存亚胺菌(CAS号:136470-79-6)?

亚胺菌应储存在干燥、阴凉处,避免直接暴露于光线下。建议使用密封容器储存,防止吸潮和污染。具体的储存条件应参考产品的安全数据表(MSDS)或药品说明书。

136470-79-6Abacavir EP Impurity...
化合物问答

2-氯-2,2-二氟乙酰胺(CAS号:354-28-9)应用于哪些行业?

2-氯-2,2-二氟乙酰胺在医药、聚合物、传感器、半导体等领域有广泛应用。在医药领域,它作为中间体用于合成其他药物;在聚合物领域,用作聚合引发剂或稳定剂;在传感...

354-28-92-Chloro-2,2-difluor...
化合物问答

处理4-甲基-3-硝基-1,1-联苯(CAS号:53812-68-3)时应注意哪些实验室安全事项?

在处理4-甲基-3-硝基-1,1-联苯时,应佩戴手套、护目镜和实验室外套等个人防护装备(PPE),确保在通风橱中操作以减少吸入风险。若发生泄露,应立即使用沙子或...

53812-68-34'-Methyl-3-nitro-1,...
化合物问答

(2S)-羟基(苯基)乙酸 (2R)-N-苄基-1-(4-甲氧基苯基)丙-2-胺盐(CAS号:188690-84-8)应用于哪些行业?

该化合物广泛应用于医药、聚合物和半导体行业。在医药领域,它是某些药物中间体的重要组成部分;在聚合物领域,可用作增塑剂;在半导体行业,可用于制造光刻胶。

188690-84-8Benzeneacetic acid, ...
化合物问答

在合成中是否有芬苯哒唑砜-D3标准品(CAS号:1228182-49-7)的替代品?

芬苯哒唑砜-D3标准品的替代品可能包括类似的苯并咪唑类化合物,如芬苯哒唑本身或其非同位素标记版本。这些替代品在结构上与芬苯哒唑砜-D3相似,但在具体应用中需进行...

1228182-49-7(~2~H_3_)Methyl [5-(...
化合物问答

2-氟-4-硝基苯乙酸(CAS号:315228-19-4)通常如何合成?

2-氟-4-硝基苯乙酸可以通过一系列化学反应合成,通常是从4-氟苯胺开始,首先进行硝化反应生成4-氟-2-硝基苯胺,然后进行乙酰化反应得到目标产物。具体的合成步...

315228-19-42-(2-fluoro-4-nitrop...
化合物问答

2-氟-4-甲氧基苯乙酸(CAS号:883531-28-0)通常如何合成?

2-氟-4-甲氧基苯乙酸通常通过将4-甲氧基苯乙酸与氟化试剂(如氟化氰)反应来合成。反应通常在无水条件下进行,使用催化剂如六氟磷酸锂或四氟硼酸锂以提高选择性和产...

883531-28-02-Fluoro-4-methoxyph...
化合物问答

什么是4SC 202;4SC202(CAS号:1186222-89-8)?

4SC 202;4SC202是一种化学化合物,其化学名称为(2E)-N-(2-氨基苯基)-3-(1-{[4-(1-甲基-1H-吡唑-4-基)苯基]磺酰基}-1H...

1186222-89-8(2E)-N-(2-Aminopheny...
化合物问答

如何储存3,5-二氟苯甲酰胺(CAS号:132980-99-5)?

3,5-二氟苯甲酰胺应储存在阴凉、干燥、通风良好的地方,避免高温和直射阳光。最好使用密封的容器存储,以减少吸湿。

132980-99-53,5-Difluorobenzamid...

来源期刊

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
自引率: 10.3%
年发文量: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。