Functional block copolymernanoparticles: toward the next generation of delivery vehicles
文献信息
发布日期
2012-04-18
DOI
10.1039/C2PY20131C
影响因子
5.582
作者
Maxwell J. Robb, Luke A. Connal, Bongjae F. Lee, Nathaniel A. Lynd
查看原文
摘要
The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyes via copper catalyzed azide alkyne cycloaddition ‘click’ chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditions via the degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.
相关文献
Camptothecin prodrug block copolymer micelles with high drug loading and target specificity
Sue Watson, Anna M. Grabowska
2014-05-15
Paper
DOI: 10.1039/C4PY00369A
Blood compatibility of heparin-inspired, lactose containing, polyureas depends on the chemistry of the polymer backbone
Y. Huang, M. A. Shaw, M. R. Warmin, E. S. Mullins, N. Ayres
2016-05-13
Paper
DOI: 10.1039/C6PY00616G
tBCPMA: a new trifunctional acrylic monomer for convenient synthesis of a well-defined amphiphilic graft copolymer by successive RDRP
Chun Feng, Guolin Lu, Gang Sun, Xunwei Liu, Xiaoyu Huang
2014-06-30
Paper
DOI: 10.1039/C4PY00772G
Controlled polymerization of isoprene promoted by a type of hemilabile XPN3 (X = O, S) ligand supported cobalt(ii) complexes: the role of a hemilabile donor on the level of control
Huafeng Chen, Weijing Pan, Kuo-Wei Huang, Xuequan Zhang, Dirong Gong
2017-02-20
Paper
DOI: 10.1039/C7PY00252A
Dual-stimuli responsive liposomes using pH- and temperature-sensitive polymers for controlled transdermal delivery
Takumi Sugimoto, Mitsuhiro Fukushima, Ryoma Teranishi, Aki Kotaka, Chiharu Shinde, Takayuki Kumei, Yasushi Sumida, Yuki Munekata, Kei-ichi Maruyama, Eiji Yuba, Atsushi Harada, Kenji Kono
2017-02-03
Paper
DOI: 10.1039/C6PY01754A
Synthesis of highly branched polymers by reversible complexation-mediated copolymerization of vinyl and divinyl monomers
Hongjun Yang, Zhongrui Wang, Yulei Zheng, Wenyan Huang, Xiaoqiang Xue, Bibiao Jiang
2017-02-21
Paper
DOI: 10.1039/C7PY00174F
Controlling the folding of conjugated polymers at the single molecule level via hydrogen bonding
Beiyue Shao, Xinju Zhu, Kyle N. Plunkett, David A. Vanden Bout
2017-01-06
Paper
DOI: 10.1039/C6PY01871H
Fibril-shaped aggregates of doxorubicin with poly-l-lysine and its derivative
Feiyan Zhu, Yongri Liang, Fuxin Liang, Qian Wang, Jiaoli Li, Zhibo Li, Zhenzhong Yang
2014-06-10
Paper
DOI: 10.1039/C4PY00686K
Facile conversion of plant oil (anethole) to a high-performance material
Yangqing Tao, Fengkai He, Kaikai Jin, Jiajia Wang, Yuanqiang Wang, Junfeng Zhou, Jing Sun, Qiang Fang
2017-02-20
Paper
DOI: 10.1039/C7PY00047B
Oxygen and carbon dioxide dual gas-responsive homopolymers and diblock copolymers synthesized via RAFT polymerization
Xue Jiang, Guolin Lu, Huang Xiaoyu
2016-12-26
Paper
DOI: 10.1039/C6PY02004F
您可能还喜欢
化合物问答
4,5-二甲基-2-硝基苯甲酸(CAS号：4315-14-4)的市场或研究趋势如何？
4,5-二甲基-2-硝基苯甲酸主要应用于制药、染料和农药等行业。由于其潜在的毒性，其市场趋势可能受到法规限制和环保考量的影响，推动了替代产品的研发。在研究领域，...
4315-14-44,5-Dimethyl-2-nitro...
化合物问答
处理直接黑22(CAS号：6473-13-8)时应注意哪些实验室安全事项？
处理直接黑22时应穿戴适当的个人防护装备（PPE），包括实验服、手套、护目镜和口罩。操作应在通风橱内进行，以避免吸入有害气体。如果发生泄漏，应立即清理，并使用大...
6473-13-82-Naphthalenesulfoni...
化合物问答
处理2,1,3-苯并噻二唑-4-基异氰酸酯(CAS号：342411-14-7)时应注意哪些实验室安全事项？
处理2,1,3-苯并噻二唑-4-基异氰酸酯时应注意以下安全事项：穿戴个人防护装备，如实验室外套、防护眼镜和手套；在通风橱中操作，确保良好的通风；保持实验室环境干...
342411-14-74-Isocyanato-2,1,3-b...
化合物问答
如何处理含有Δ-8,9-脱氢雌酮(CAS号：204077-66-7)的废料？
含有Δ-8,9-脱氢雌酮的废料需要进行适当的处理以确保环境和人体安全。首先，收集废液并存放于密封容器中，避免泄漏。其次，可以考虑将其转化为无害物质或通过专业处理...
204077-66-7Thioquinapiperifil d...
化合物问答
如何储存5-溴戊酸(CAS号：2067-33-6)？
5-溴戊酸应储存在阴凉、干燥、通风良好的环境中，避免阳光直射。建议在室温（约15-25°C）下保存，保持相对湿度低于60%。应使用密封的玻璃或塑料容器，并远离热...
2067-33-65-Bromopentanoic aci...
化合物问答
4-(甲基亚磺酰基)苯胺(CAS号：22865-62-9)应用于哪些行业？
4-(甲基亚磺酰基)苯胺在医药、聚合物和传感器等领域有一定的应用。在医药方面，它可以用作合成药物的中间体；在聚合物领域，可以作为合成特殊性能高分子材料的单体；在...
22865-62-94-Methylsulfinylanil...
化合物问答
什么是1-(2-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOHYDRAZIDE(CAS号：618092-58-3)？
1-(2-氟苯基)-5-甲基-1H-吡唑-4-亚甲基肼是一种有机化合物，其分子式为C9H9FN3O。该化合物具有特定的物理化学性质，如熔点、沸点等，但具体值需查...
618092-58-31-(2-Fluorophenyl)-5...
化合物问答
Dauricumine(CAS号：345641-00-1)通常如何合成？
Dauricumine通常通过复杂的合成路线制备，涉及多个步骤，包括环化、氧化、卤化等反应。合成过程中使用了多种催化剂和试剂，例如金属催化剂、氧化剂等。产率通常...
345641-00-1(1R,1'S,5R,6'S,8'S)-...
化合物问答
5-氰基苯酞(CAS号：82104-74-3)安全吗？
5-氰基苯酞在正常使用条件下相对安全，但其具有一定的毒性，需谨慎操作。在实验或工业应用中，应采取适当的防护措施，如佩戴防护手套、护目镜和实验服，确保通风良好。误...
82104-74-31-Oxo-1,3-dihydro-2-...
化合物问答
2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-amine(CAS号：1186502-59-9)安全吗？
该化合物在使用时需要谨慎操作。虽然其毒性和健康风险尚未完全明确，但建议在通风良好的环境中操作，并穿戴适当的个人防护装备，如手套和防护眼镜。
1186502-59-92-Methyl-1-(phenylsu...
来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
推荐化合物
推荐供应商
免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联，也不处理投稿事宜。如有投稿相关咨询，请直接联系相关期刊出版商。
如发现页面信息有误，请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。