Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

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发布日期 2012-05-30

DOI 10.1039/C2PY20309J

影响因子 5.582

作者

Sophie Monge, Sarah Antoniacomi, Vincent Lapinte, Vincent Darcos, Jean-Jacques Robin

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摘要

The present contribution reports on an original new class of acid-labile thermosensitive polyacrylamides, namely poly(tris(hydroxymethyl)acrylamidomethane-co-(5-acrylamido-5-hydroxymethyl-2,2-dimethyl-1,3-dioxane)) (P(THAM-co-pTHAM)), in which pTHAM only differed from THAM by an acetal group. The lower critical solution temperature (LCST) was controlled by varying the comonomer composition. Additionally, the properties of these new statistical copolymers were investigated and proved that such chemical structures were interesting for smart applications, notably for drug delivery due to the biocompatibility of low molecular weight PTHAM already demonstrated.

期刊推荐

Saudi Pharmaceutical Journal

Russian Journal of Applied Chemistry

Russian Journal of General Chemistry

Russian Journal of Coordination Chemistry

Russian Journal of Bioorganic Chemistry

Organic Process Research & Development

Journal of Peptide Science

Drug Discovery Today

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Current Opinion in Solid State & Materials Science

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

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