High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase

文献信息

发布日期 2013-12-17

DOI 10.1039/C3AN02029K

影响因子 4.616

作者

Juliana Cristina Barreiro, Tiago de Campos Lourenço, Lorena Mara A. Silva, Tiago Venâncio, Quezia Bezerra Cass

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摘要

Polysaccharide-based chiral stationary phases (CSP) demonstrate great versatility and higher chiral selectivity for a variety of chiral compounds in multimodal elution modes (normal, reverse and polar organic). The main role of CSP phenyl carbamate based derivatives as chiral selectors is the formation of diastereoisomeric complexes by means of π–π interaction, dipole–dipole, hydrogen bonding and/or inclusion complex mechanisms. Nevertheless, the mechanism behind their enantioselectivity requires clarification. High resolution magic angle spinning nuclear magnetic resonance spectroscopy (1H HR/MAS NMR) has provided key information on the recognition process at the binding sites of the CSP surface. Herein we report the results obtained using omeprazole as a probe for these investigations.

期刊推荐

Planta Medica

Journal of Heterocyclic Chemistry

Journal of Catalysis

Nature

Journal of Organometallic Chemistry

Fibre Chemistry

Kinetics and Catalysis

Pure and Applied Chemistry

Russian Chemical Reviews

Proceedings of the National Academy of Sciences of the United States of America

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase

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