Cancer antigen 125 detection using the plasmon resonance scattering properties of gold nanorods

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发布日期 2013-01-21

DOI 10.1039/C3AN36614F

影响因子 4.616

作者

Kaixia Zhang, Xiaolei Shen

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摘要

Cancer antigen 125 (CA 125) is a useful tumor marker with a threshold value of 35 U mL−1 expressed by more than 80% of patients with non-mucinous epithelial ovarian cancer. In this work, a novel strategy for the analysis of CA 125 using the plasmon resonance scattering (PRS) properties of gold nanorods was proposed. The gold nanorod (GNR)–anti-CA 125 conjugates were prepared first. The immunoreaction between the GNR modified CA 125 antibody and CA 125 took place in aqueous solution after the addition of CA 125. The target protein concentration was determined by analyzing the level of GNR aggregation caused by CA 125 antibody–antigen interactions using PRS. At a concentration of 1.0–80 U mL−1, CA 125 could be determined with a detection limit of 0.4 U mL−1. The PRS immunosensor showed high sensitivity, selectivity, and reproducibility. Determination of CA 125 in serum samples showed good recovery.

期刊推荐

Foundations of Chemistry

Journal of Enzyme inhibition and Medicinal Chemistry

Journal of Medical Biochemistry

CrystEngComm

Mini-Reviews in Medicinal Chemistry

Molecules

Photochemical & Photobiological Sciences

Molecular Diversity

Angewandte Chemie International Edition

Environmental Toxicology and Pharmacology

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Cancer antigen 125 detection using the plasmon resonance scattering properties of gold nanorods

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