A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡

文献信息

发布日期 2013-04-08

DOI 10.1039/C3PY00347G

影响因子 5.582

作者

Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent

查看原文

摘要

A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of α-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.

期刊推荐

Synlett

Current Medicinal Chemistry

Composite Interfaces

Main Group Metal Chemistry

Advanced Powder Technology

Heterocyclic Communications

Journal of Computer-Aided Molecular Design

Advanced Materials

Cement and Concrete Composites

Construction and Building Materials

相关文献

Self-assembled zinc(ii) Schiff basepolymers for applications in polymer light-emitting devices

Chi-Chung Kwok, Sze-Chit Yu, Iona H. T. Sham, Chi-Ming Che

2004-10-20 Communication

DOI: 10.1039/B412762E

Chiral amplification by polypeptides and its relevance to prebiotic catalysis

David R. Kelly, Alastair Meek, Stanley M. Roberts

2004-08-25 Communication

DOI: 10.1039/B404379K

Synthesis and electropolymerization of novel oligothiophene-functionalized perylene bisimides

Chang-Cheng You, Chantu R. Saha-Möller, Frank Würthner

2004-08-06 Communication

DOI: 10.1039/B407551J

A new packing motif for para-sulfonatocalix[4]arene: the solid state structure of the para-sulfonatocalix[4]arene d-arginine complex

Adina Lazar, Eric Da Silva, Alda Navaza, Carole Barbey, Anthony W. Coleman

2004-08-20 Communication

DOI: 10.1039/B408863H

Estimates of internal energies of vaporisation of some room temperature ionic liquids

Konrad Swiderski, Andrew McLean, Charles M. Gordon, D. Huw Vaughan

2004-09-07 Communication

DOI: 10.1039/B408334B

Novel fullerene–porphyrin–fullerene triad linked by metal axial coordination: Synthesis, X-ray crystal structure, and spectroscopic characterizations of trans-bis([60]fullerenoacetato)tin(iv) porphyrin

Hyun Jung Kim, Ki-Min Park, Seong Keun Kim, Kil Suk Kim, Dongho Kim, Hee-Joon Kim

2004-09-30 Communication

DOI: 10.1039/B411482E

Fabrication and photoluminescence of chemically stable La2O3:Eu3+–La2Sn2O7 core–shell-structured nanoparticles

Eiji Hosono, Shinobu Fujihara

2004-08-13 Communication

DOI: 10.1039/B408495K

A samarium cyclooctatetraene complex as catalyst for hydroamination/cyclisation catalysis

Agustino Zulys, Tarun K. Panda, Michael T. Gamer, Peter W. Roesky

2004-09-30 Communication

DOI: 10.1039/B410918J

An unprecedented intramolecular coupling of o-carboranyl and cyclopentadienyl. Synthesis and structural characterization of a ruthenium complex containing a novel doubly-bridged cyclopentadienyl-carboranyl ligand

Yi Sun, Hoi-Shan Chan, Pierre H. Dixneuf, Zuowei Xie

2004-09-30 Communication

DOI: 10.1039/B409772F

Unexpected oxidative C–C cleavage in the metallation of 2-substituted imidazolium salts to give N-heterocyclic carbene complexes

Anthony R. Chianese, Brian M. Zeglis, Robert H. Crabtree

2004-08-25 Communication

DOI: 10.1039/B409672J

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡

文献信息

期刊推荐

相关文献

Self-assembled zinc(ii) Schiff basepolymers for applications in polymer light-emitting devices

Chiral amplification by polypeptides and its relevance to prebiotic catalysis

Synthesis and electropolymerization of novel oligothiophene-functionalized perylene bisimides

A new packing motif for para-sulfonatocalix[4]arene: the solid state structure of the para-sulfonatocalix[4]arene d-arginine complex

Estimates of internal energies of vaporisation of some room temperature ionic liquids

Novel fullerene–porphyrin–fullerene triad linked by metal axial coordination: Synthesis, X-ray crystal structure, and spectroscopic characterizations of trans-bis([60]fullerenoacetato)tin(iv) porphyrin

Fabrication and photoluminescence of chemically stable La2O3:Eu3+–La2Sn2O7 core–shell-structured nanoparticles

A samarium cyclooctatetraene complex as catalyst for hydroamination/cyclisation catalysis

An unprecedented intramolecular coupling of o-carboranyl and cyclopentadienyl. Synthesis and structural characterization of a ruthenium complex containing a novel doubly-bridged cyclopentadienyl-carboranyl ligand

Unexpected oxidative C–C cleavage in the metallation of 2-substituted imidazolium salts to give N-heterocyclic carbene complexes

您可能还喜欢

如何处理含有3-氯苯甲酰肼(CAS号：1673-47-8)的废料？

(2E)-N-(2-氨基-4-氟苯基)-3-[1-(3-苯基-2-丙烯-1-基)-1H-吡唑-4-基]-2-丙烯酰胺(CAS号：1396841-57-8)应用于哪些行业？

什么是对-N,N-二甲氨基苯甲酸乙酯(CAS号：10287-53-3)？

3,6-二溴-9-(4-甲基苯基)-9H-咔唑(CAS号：357437-74-2)的物理化学性质是什么？

在合成中是否有FMOC-(2R,4S)-PRO(4-F)-OH(CAS号：913820-87-8)的替代品？

2-苄基八氢环戊并[c]吡咯-4-胺(CAS号：186201-60-5)的主要用途是什么？

奥氮平N乙酰基杂质(CAS号：935272-10-9)的市场或研究趋势如何？

处理Chloropropylate(CAS号：5836-10-2)时应注意哪些实验室安全事项？

在合成中是否有4-氢氯化氨基安替比林(CAS号：22198-72-7)的替代品？

如何处理含有3-脱氧-D-葡糖酮醛(CAS号：4084-27-9)的废料？

来源期刊

Polymer Chemistry

推荐化合物

L-Arginine

Isobutylboronic acid

Zinc oxide

Pentasodium Triphosphate

Sodium (2S)-2-hydroxypropanoate

推荐供应商