Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

文献信息

发布日期 2013-08-15

DOI 10.1039/C3PY00991B

影响因子 5.582

作者

Daniel J. Phillips, Joseph P. Patterson, Rachel K. O'Reilly, Matthew I. Gibson

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摘要

The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a ‘solubility release catch’ at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an ‘isothermal’ response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products.

期刊推荐

Drug Discovery Today

Russian Journal of Coordination Chemistry

New Journal of Chemistry

Russian Chemical Bulletin

Current Opinion in Solid State & Materials Science

Saudi Pharmaceutical Journal

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Russian Journal of General Chemistry

Organic Process Research & Development

Chemical Communications

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

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