Facile fabrication and application of near-IR light-responsive drug release system based on gold nanorods and phase change material

文献信息

发布日期 2014-10-07
DOI 10.1039/C4TB01631A
影响因子 6.331
作者

Junseok Lee, Cherlhyun Jeong, Won Jong Kim


查看原文

摘要

Near-IR (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and the high biological penetration of NIR. This work describes the facile fabrication and anticancer effect of a NIR-responsive drug delivery system based on the nano-assembly of mesoporous silica-coated gold nanorods (AuNR@mSiO2) and a phase change material (PCM). The core gold nanorods in AuNR@mSiO2 provided excellent NIR sensitivity, and the mesoporous silica shell provided an increased reservoir of loaded drug. The PCM was applied as both a thermosensitive gatekeeper and a medium for a hydrophobic anticancer drug. The photothermal effect of the AuNRs under NIR irradiation facilitated a rapid release of the drug through the temperature-sensitive phase transition of PCM at just above body temperature. An enhanced anticancer effect was observed against various cell lines, and intracellular release of the drug was easily monitored by live cell imaging. Our system does not require any complicated synthetic methods for fabrication, and PCM is easily capable of solubilizing various hydrophobic drugs. Therefore, this system has significant potential for broad application in the biomedical field as a delivery system for hydrophobic drugs with NIR-responsive behavior.

相关文献

C2 product formation in the CO2 electroreduction on boron-doped graphene anchored copper clusters

Balázs Barhács, Ewald Janssens

2022-08-29 Paper

DOI: 10.1039/D2CP01316A

Adsorption properties of pyramidal superatomic molecules based on the structural framework of the Au20 cluster

Manli Zhang, Dawen Zhang, Yunhu Hu, Qiyong Zhu, Longjiu Cheng

2022-05-02 Paper

DOI: 10.1039/D2CP01552H

A new ratiometric switch “two-way” detects hydrazine and hypochlorite via a “dye-release” mechanism with a PBMC bioimaging study

Lakshman Patra, Partha Pratim Das, Kakali Ghoshal, Saswati Gharami, James W. Walton, Maitree Bhattacharyya, Tapan Kumar Mondal

2022-09-02 Paper

DOI: 10.1039/D2CP02482A

Mutual effects between single-stranded DNA conformation and Na+–Mg2+ ion competition in mixed salt solutions

Li-Zhen Sun, Jun-Lin Qian, Pinggen Cai, Xiaojun Xu

2022-08-19 Paper

DOI: 10.1039/D2CP02737B

Effect of sodium chloride adsorption on the surface premelting of ice

Margaret L. Berrens, Fernanda C. Bononi, Davide Donadio

2022-08-20 Paper

DOI: 10.1039/D2CP02277J

Back cover

2022-09-14 Cover

DOI: 10.1039/D2CP90171D

DLSSAffinity: protein–ligand binding affinity prediction via a deep learning model

Huiwen Wang, Haoquan Liu, Shangbo Ning, Chengwei Zeng, Yunjie Zhao

2022-04-04 Paper

DOI: 10.1039/D1CP05558E

Mechanistic insight into the disruption of Tau R3–R4 protofibrils by curcumin and epinephrine: an all-atom molecular dynamics study

Yu Zou, Bote Qi, Jingwang Tan, Yehong Gong, Qingwen Zhang

2022-08-08 Paper

DOI: 10.1039/D2CP02353A

Infrared photodissociation spectroscopy of (Al2O3)2–5FeO+: influence of Fe-substitution on small alumina clusters

Marcel Jorewitz, Knut R. Asmis, Julius B. Stückrath, Florian A. Bischoff, Joachim Sauer

2022-08-15 Paper

DOI: 10.1039/D2CP02938C

您可能还喜欢

化合物问答

什么是2-Bromo-1-(pyrimidin-2-yl)ethanone hydrobromide(CAS号:1588441-02-4)?

2-Bromo-1-(pyrimidin-2-yl)ethanone hydrobromide是一种有机化合物,分子式为C6H5Br2N2O2。它是一种溴代化合...

1588441-02-42-Bromo-1-(2-pyrimid...
化合物问答

在合成中是否有1-正-丁基-3-甲基咪唑鎓三氟甲烷磺酸盐(CAS号:174899-66-2)的替代品?

在合成中,可以考虑使用1-正-丁基-3-甲基咪唑鎓溴酸盐或1-正-丁基-3-甲基咪唑鎓氯酸盐作为替代品。这些化合物在性能上与1-正-丁基-3-甲基咪唑鎓三氟甲烷...

174899-66-21-Butyl-3-methyl-1H-...
化合物问答

2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid(CAS号:651005-90-2)的市场或研究趋势如何?

目前,2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid的研究主要集中在药物化学和新型材料领域。随着生物医药和有机合...

651005-90-22-Methyl-5-(thien-2-...
化合物问答

格列吡嗪杂质H(CAS号:13554-93-3)的主要用途是什么?

格列吡嗪杂质H主要作为药物中间体或副产物存在,并无特定的工业应用。在药物生产中,它可能需要被处理掉以保证最终药物的质量。

13554-93-3Ethyl (2-(4-((cycloh...
化合物问答

如何储存(9ci)-4-甲氧基-1H-苯并咪唑-2-乙腈(CAS号:317817-41-7)?

(9ci)-4-甲氧基-1H-苯并咪唑-2-乙腈应储存在阴凉、干燥、通风良好的地方,避免阳光直射。使用密封的玻璃或塑料容器储存,并确保容器的密封性良好,以防止挥...

317817-41-7(4-Methoxy-1H-benzim...
化合物问答

4,5,9,10-四氢苯芘(CAS号:781-17-9)应用于哪些行业?

4,5,9,10-四氢苯芘在医药行业用于作为某些药物的中间体,在聚合物行业用作添加剂提升材料的热稳定性,在传感器领域作为传感器的敏感材料,在半导体行业中用作掺杂...

781-17-94,5,9,10-Tetrahydrop...
化合物问答

处理叶酸-D4(CAS号:171777-72-3)时应注意哪些实验室安全事项?

处理叶酸-D4时应佩戴个人防护装备(PPE),如手套和实验服。操作应在通风橱内进行,以避免吸入蒸汽或粉尘。如果不慎泄露,应立即用大量清水冲洗,并通知安全人员。参...

171777-72-3Folic Acid-d4
化合物问答

如何处理含有6-溴-2-(三氟乙酰基)-1,2,3,4-四氢异喹啉(CAS号:252331-63-8)的废料?

含有该化合物的废料应收集到专用的容器中,并进行密封以防止挥发和泄漏。在处理前,需进行危险性评估,以确定是否需要进行化学处理。最终处置需遵循当地的危险废物管理规定...

252331-63-81-(6-bromo-3,4-dihyd...
化合物问答

4,5-二氟-2-甲氧基苯甲醛(CAS号:145742-34-3)的主要用途是什么?

4,5-二氟-2-甲氧基苯甲醛主要用作有机合成中的中间体,特别是在制药和农药领域。它可以作为合成其他有机化合物的原料。

145742-34-34,5-difluoro-2-metho...
化合物问答

5-溴-6-三氟甲基吲哚(CAS号:1198475-24-9)安全吗?

5-溴-6-三氟甲基吲哚作为一种化学试剂,具有一定的毒性,需要在通风橱中操作,并采取适当的安全措施以避免吸入、皮肤接触和眼睛刺激。应避免与皮肤和眼睛直接接触,并...

1198475-24-95-bromo-6-(trifluoro...

来源期刊

Journal of Materials Chemistry B

Journal of Materials Chemistry B
CiteScore: 12
自引率: 4.9%
年发文量: 831

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。