A highly sensitive DNA sensor for attomolar detection of the BRCA1 gene: signal amplification with gold nanoparticle clusters

文献信息

发布日期 2015-02-05

DOI 10.1039/C5AN00004A

影响因子 4.616

作者

P. Abdul Rasheed, N. Sandhyarani

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摘要

Single stranded DNA fragments were conjugated onto gold nanoparticles leading to the formation of gold nanoparticle clusters upon hybridization with complementary strands. These clusters were successfully implemented for signal amplification in an electrochemical DNA sensor based on a graphene substrate. The sensor exhibited excellent sensitivity and selectivity with a detection limit of 50 attomolar target DNA.

期刊推荐

AIAA Journal

Accounts of Chemical Research

Biopolymers

Journal of the Chinese Chemical Society

Doklady Chemistry

Australian Journal of Chemistry

Chemistry of Heterocyclic Compounds

Carbon

Ferroelectrics

Journal of the American Chemical Society

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A highly sensitive DNA sensor for attomolar detection of the BRCA1 gene: signal amplification with gold nanoparticle clusters

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