Facile synthesis of drug-conjugated PHPMA core-crosslinked star polymers

文献信息

发布日期 2015-05-13

DOI 10.1039/C5PY00497G

影响因子 5.582

作者

Bryan S. Tucker, Stephen G. Getchell, Megan R. Hill, Brent S. Sumerlin

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摘要

Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA), a biocompatible and non-immunogenic polymer, was used to form core-crosslinked star polymers for potential drug delivery applications. The conditions for the formation of the PHPMA stars were studied by varying the molecular weight of the PHPMA unimers, [crosslinker] : [unimer] ratios, and solvent. The optimized conditions were then used to form drug-loaded PHPMA star polymers by directly copolymerizing an HPMA-modified anticancer drug, methotrexate, during the crosslinking reaction of PHPMA unimers. The incorporation of the drug was confirmed by 1H NMR spectroscopy, and UV-visible spectroscopy was used to determine a drug loading of 20 wt%. Our initial drug release studies showed that the addition of an esterase induced drug release.

期刊推荐

Nature Reviews Drug Discovery

Green Chemistry

Photochemical & Photobiological Sciences

Journal of Enzyme inhibition and Medicinal Chemistry

Molecular Diversity

Angewandte Chemie International Edition

Coloration Technology

European Journal of Organic Chemistry

Environmental Toxicology and Pharmacology

Physical Chemistry Chemical Physics

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Facile synthesis of drug-conjugated PHPMA core-crosslinked star polymers

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Polymer Chemistry

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