An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor
文献信息
Lilong Gao, Guangyu Zha, Qiaojie Luo, Weipu Zhu, Zhiquan Shen, Xiaodong Li
We developed a facile strategy to prepare an injectable drug-loaded hydrogel with chemical crosslinkages. A PCL-POEGM-PCL amphiphilic triblock copolymer was synthesized in “one pot” by a combination of polycondensation and ring-opening polymerization, which can disperse hydrophobic drugs in aqueous solution and be crosslinked by POEGMS under physiological conditions.
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