Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

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发布日期 2015-11-16

DOI 10.1039/C5PY01467K

影响因子 5.582

作者

Nghia P. Truong, Michael R. Whittaker, John F. Quinn

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摘要

Thermoresponsive polymers are used to produce nanoparticles or nanoaggregates for a wide range of applications such as nanomedicine. However, low-toxicity, thermoresponsive polymers such as methacrylate polymers with short oligo(ethylene glycol) side chains are not readily applicable to the synthesis of nanoaggregates with both spherical and nonspherical morphologies. Here we report the synthesis of a low-toxicity, thermoresponsive copolymer, P(DEGMA-co-HPMA), and describe its application in the RAFT-mediated emulsion polymerization of styrene as a means to produce nanoparticles with tuneable morphology (sphere, cylinder, vesicle and lamella). These nanoaggregates offer considerable potential as a novel platform for the next generation of nanotherapeutics with improved efficacy.

期刊推荐

Crystallography Reports

Saudi Pharmaceutical Journal

New Journal of Chemistry

Chemical Communications

Russian Chemical Bulletin

Acta Materialia

Russian Journal of Bioorganic Chemistry

Current Opinion in Colloid & Interface Science

Chemistry Education Research and Practice

Current Opinion in Solid State & Materials Science

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

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