Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I)
文献信息
发布日期
2016-01-06
DOI
10.1039/C5QO00354G
影响因子
5.281
作者
Can-Liang Ma, Xiao-Hua Li, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong, Bin Tan, Xin-Yuan Liu
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摘要
The Au-catalyzed tandem process of aminoalkynes was explored, providing simple and efficient access to richly functionalized dipyrroloquinoline frameworks with good to excellent yields. The reaction exhibits great efficiency and high atom economy in multiple-bond formation for constructing bioactive azaspiro polycyclic molecules with densely multiple stereogenic centers including quaternary carbons, and shows a broad substrate scope and synthetically important functional group tolerance, which have been illustrated in the first one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I).
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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