An ultrasensitive electrochemical immunosensor based on the synergistic effect of quaternary Cu2SnZnS4 NCs and cyclodextrin-functionalized graphene

文献信息

发布日期 2017-01-17

DOI 10.1039/C6AN02538B

影响因子 4.616

作者

Lei Liu, Yihe Zhang, Ruifeng Du, Jinhong Li, Xuelian Yu

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摘要

In this study, highly monodispersed Cu2SnZnS4 NCs with a quasi-spherical structure were prepared to construct a sandwich-type electrochemical immunosensor for alpha-fetoprotein detection. Quaternary Cu2SnZnS4 NCs as novel biomimetic catalysts show an efficient intrinsic peroxidase-like activity for H2O2 reduction. This excellent catalytic activity is ascribed to the higher electroconductivity than those of the binary Cu2S and ternary Cu2SnS3 NCs. Moreover, β-cyclodextrin-functionalized graphene sheets are used as substrate materials that can capture large amounts of primary antibodies due to host–guest interaction and high surface area. Under the optimized conditions, the electrochemical immunosensor exhibites a wide working range from 0.5 pg mL−1 to 10 ng mL−1 and a detection limit of 0.16 pg mL−1 at a signal-to-noise ratio of 3. Good sensitivity, reproducibility, and stability demonstrate its potential application in clinical diagnostics.

期刊推荐

Journal of Enzyme inhibition and Medicinal Chemistry

Molecular Diversity

Faraday Discussions

Physical Chemistry Chemical Physics

Photochemical & Photobiological Sciences

Journal of Medical Biochemistry

Contact Lens & Anterior Eye

Nature Reviews Drug Discovery

Current Pharmaceutical Biotechnology

Advanced Engineering Materials

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

An ultrasensitive electrochemical immunosensor based on the synergistic effect of quaternary Cu2SnZnS4 NCs and cyclodextrin-functionalized graphene

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