Phase behavior of lysozyme solutions in the liquid–liquid phase coexistence region at high hydrostatic pressures
文献信息
Julian Schulze, Johannes Möller, Jonathan Weine, Karin Julius, Nico König, Julia Nase, Michael Paulus, Metin Tolan, Roland Winter
We present results from small-angle X-ray scattering and turbidity measurements on the effect of high hydrostatic pressure on the phase behavior of dense lysozyme solutions in the liquid–liquid phase separation region, and characterize the underlying intermolecular protein–protein interactions as a function of temperature and pressure under charge-screening conditions (0.5 M NaCl). A reentrant liquid–liquid phase separation region is observed at elevated pressures, which may originate in the pressure dependence of the solvent-mediated protein–protein interaction. A temperature-pressure-concentration phase diagram was constructed for highly concentrated lysozyme solutions over a wide range of temperatures, pressures and protein concentrations including the critical region of the liquid–liquid miscibility gap.
期刊推荐

Journal of Saudi Chemical Society

Russian Journal of Coordination Chemistry

Organic Process Research & Development

Chemistry Education Research and Practice

Current Opinion in Colloid & Interface Science

Russian Chemical Bulletin

New Journal of Chemistry

Saudi Pharmaceutical Journal

Russian Journal of General Chemistry

Russian Journal of Organic Chemistry
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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.
![1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure 1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure](https://cnstatic.chemtradehub.com/structs/143/1434747-57-5-fc0d.webp)



