Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

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发布日期 2017-01-04

DOI 10.1039/C6PY01719C

影响因子 5.582

作者

Sigen A, Qian Xu, Dezhong Zhou, Yongsheng Gao, Jeddah Marie Vasquez, Udo Greiser, Wenguang Liu

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摘要

Star-shaped poly(ethylene glycol)-N-hydroxysuccinimide (star-PEG-NHS) has shown great promise in a variety of biomedical applications owing to its non-toxicity, innate non-immunogenic properties and versatile, multifunctional end groups. However, its complex and sophisticated synthetic methods, as well as high costs, have significantly impeded its wide application. Here, we report the design and synthesis of a hyperbranched PEG-based polymer with multiple NHS functional groups (>12). The hyperbranched PEG-based multi-NHS polymer can react easily with a protein (bovine serum albumin, BSA) to form a PEG-protein hydrogel that displays great potential for biomedical applications.

期刊推荐

Russian Journal of Coordination Chemistry

Russian Chemical Bulletin

Chemical Communications

Current Opinion in Colloid & Interface Science

Drug Discovery Today

Organic Process Research & Development

Journal of Peptide Science

Current Opinion in Solid State & Materials Science

Journal of Saudi Chemical Society

Crystallography Reports

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

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来源期刊

Polymer Chemistry

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