Ultra-pH-sensitive polypeptide micelles with large fluorescence off/on ratio in near infrared range

文献信息

发布日期 2016-12-16

DOI 10.1039/C6PY01818A

影响因子 5.582

作者

Liyi Fu, Pan Yuan, Zheng Ruan, Le Liu, Tuanwei Li, Lifeng Yan

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摘要

An amphiphilic copolymer of poly(oligo(ethylene glycol) methacrylate) (POEGMA) and poly(benzyl-L-aspartic acid) (PBLA) has been prepared by means of reversible addition–fragmentation chain transfer (RAFT) polymerization, ring-opening polymerization, and click reaction. After the PBLA segment was aminolyzed by the primary amine, N,N-diisopropylethylenediamine (DIEDA) and N,N-dibutylethylenediamine (DBEDA) with different ratios, amphiphilic block copolymers with various ionizable tertiary amines have been prepared, which can form stable micelles in neutral pH by self-assembly and disassembly under weak acidic conditions. After conjugation of Cy5.5/quencher to the copolymer, the as-formed micelles exhibit low fluorescence due to the Fluorescence Resonance Energy Transfer (FRET) between Cy5.5 and the quencher. However, an ultra-pH-sensitive fluorescence can be switched-on when it was in weak acidic conditions. The as-prepared nanoparticles have potential application in highly sensitive detection of the pH of tissues and cells, and can also work as a theranostic for cancer with drug delivery and imaging ability.

期刊推荐

Journal of Saudi Chemical Society

Current Opinion in Colloid & Interface Science

New Journal of Chemistry

Current Opinion in Solid State & Materials Science

Nature Medicine

Crystallography Reports

Organic Process Research & Development

Drug Discovery Today

Russian Journal of Bioorganic Chemistry

Acta Materialia

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Ultra-pH-sensitive polypeptide micelles with large fluorescence off/on ratio in near infrared range

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来源期刊

Polymer Chemistry

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