Cobalt-catalyzed synthesis of quinolines from the redox-neutral annulation of anilides and alkynes
文献信息
发布日期
2016-03-17
DOI
10.1039/C6QO00059B
影响因子
5.281
作者
Qiangqiang Yan, Zhengkai Chen, Zhanxiang Liu
查看原文
摘要
A new method of cobalt-catalyzed annulation of anilides and internal alkynes for the efficient synthesis of quinoline scaffolds was developed. The combination of cobalt catalyst with the Lewis acid Zn(OTf)2 ensured the success of the annulation to give the quinoline heterocycles in high efficiency. The transformation is supposed to undergo ortho C–H activation and nucleophilic addition of C–Co species toward the amides. Attractive features of this system include the use of a low cost cobalt catalyst, the easy-handling operation, and readily available substrates.
期刊推荐
Journal of Asian Natural Products Research
Medicinal Chemistry Research
Topics in Catalysis
Bioorganic & Medicinal Chemistry
Atomization and Sprays
Biocatalysis and Biotransformation
Herald of the Russian Academy of Sciences
Electroanalysis
Journal of the Indian Institute of Science
Polycyclic Aromatic Compounds
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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