Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
文献信息
发布日期
2017-12-07
DOI
10.1039/C7OB02119D
影响因子
3.876
作者
Stefan Matysiak, Klaus Hellmuth, Arun Shivalingam, Yavuz Ariyurek, Marco de Jong, Martine J. Hollestelle, Ruud Out, Tom Brown
查看原文
摘要
DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.
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来源期刊
Organic & Biomolecular Chemistry
CiteScore:
3.4
自引率:
10.3%
年发文量:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
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CAS号:
1194032-23-9
分子式:
C11H17F2NO4
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