Post-synthetic diversification of pyrrole-fused benzosultams via trans-sulfonylations and reactions on the periphery of pyrrole
文献信息
Joydev K. Laha, Rohan A. Bhimpuria, Aitha Manoj Kumar
The chemistry (synthesis and reactions) of pyrrole-fused benzosultams has been the subject of this current investigation. Their workable access via palladium-catalyzed oxidative coupling has made this study feasible. The trans-sulfonylation in pyrrole-fused benzosultams provided access to otherwise unattainable (NH)-2-arylpyrroles containing an ortho-sulfonamide functionality. Other N–SO2 bond cleavages in pyrrole-fused benzosultams yielded synthetically useful (NH)-2-arylpyrroles containing other ortho-sulfonyl functionality. A terminal amine or hydroxyl functionality, ideally poised for bioconjugation, is another important feature of some of the synthesized (NH)-2-arylpyrroles. The rationally designed and synthesised novel fluorenes tethered with pyrrole-fused benzosultam could find applications as organic emitters in organic light-emitting devices (OLEDs).
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry










![[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetyloxy-15-[(2R,3S)-3-benzamido-3-phenyl-2-(2,2,2-trichloroethoxycarbonyloxy)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate structure [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetyloxy-15-[(2R,3S)-3-benzamido-3-phenyl-2-(2,2,2-trichloroethoxycarbonyloxy)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate structure](https://cnstatic.chemtradehub.com/structs/100/100431-55-8-7104.webp)



