Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source
文献信息
Shupeng Dong, Guibing Wu, Xiaoqian Yuan, Chuncheng Zou, Jinxing Ye
A convenient method mediated by photoredox catalysis for the direct construction of 1,4-dicarbonyl compounds has been developed. Simple aromatic symmetric carboxylic anhydrides or mixed anhydrides (generated in situ) have been utilized as an acyl radical source in addition to different types of Michael acceptors. A wide range of substrates are amenable to this new type of acyl Michael addition under mild conditions with broad functional group tolerance. As an application, a novel four-step synthesis of medicinal agent haloperidol is also presented.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry














