Multifunctional odorless isocyano(triphenylphosphoranylidene)-acetates: synthesis and direct one-pot four-component Ugi/Wittig cyclization to multisubstituted oxazoles
文献信息
Zhi-Lin Ren, Zhi-Rong Guan, Han-Han Kong, Ming-Wu Ding
The multifunctional odorless isocyano(triphenylphosphorany-lidene)acetate was prepared as a new stable phosphorus ylide containing isocyanide group. A new one-pot four component synthesis of multisubstituted oxazoles by a cascade Ugi/Wittig process without Mumm rearrangement has been developed, starting from the isocyano(triphenylphosphora-nylidene)acetates, aldehydes, amines and acids. Two component reactions of isocyano(triphenylphosphoranylidene)-acetates and acids also generated disubstituted oxazoles in good yields.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry














