A novel porphyrin-based near-infrared fluorescent probe for hypochlorite detection and its application in vitro and in vivo

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发布日期 2018-04-19

DOI 10.1039/C8AN00586A

影响因子 4.616

作者

Xiaoyi Wang, Jie Min, Weijie Wang, Yan Wang, Ruiyong Wang

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摘要

Reactive oxygen species (ROS), especially HOCl/ClO−, have been demonstrated to play essential roles in both physiological and pathological processes, and an abnormal level of HOCl/ClO− is related to some diseases. In this work, a very fast responsive (within 30 seconds) porphyrin-based fluorescent probe, TPP-TCF, for ClO− with a NIR emissive wavelength was prepared. This probe exhibited excellent selectivity towards ClO− and would not be interfered with by other ROS and typical nucleophiles. The limit of detection (LOD) for ClO− was evaluated to be 0.29 μM, indicating high sensitivity towards ClO−. In further bioimaging experiments, TPP-TCF displayed low-cytotoxicity and good cell penetrability for recognizing exogenous ClO− in HeLa cells. Moreover, this probe was successfully applied in imaging endogenous ClO− in living animals.

期刊推荐

Carbon

Doklady Chemistry

Chemistry of Natural Compounds

Journal of the American Chemical Society

Advances in Colloid and Interface Science

Corrosion Science

Analyst

Chemistry of Heterocyclic Compounds

Chemical Reviews

Cement and Concrete Research

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Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A novel porphyrin-based near-infrared fluorescent probe for hypochlorite detection and its application in vitro and in vivo

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