Cd2+ coordination: an efficient structuring switch for polypeptide polymers

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发布日期 2018-06-13

DOI 10.1039/C8PY00810H

影响因子 5.582

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摘要

Stimuli-responsive polypeptides have practical applications in devices and therapeutic delivery. Here we report that coordination to Cd2+ metal species can be used as a robust stimulus to control both, α-helix and β-sheet secondary structuring of polypeptide polymers whose metal responsiveness was achieved in the presence of a competitive buffer. As evidenced by circular dichroism analyses, secondary structuring can be easily reversed using “sequestering” external ligands, such as EDTA, that are widely used in industry, to finally design a multivalent polypeptide backbone combining metal responsiveness to two other stimuli, pH and redox conditions.

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Fire and Materials

Ferroelectrics Letters Section

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Journal of Analytical Atomic Spectrometry

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Ceramics International

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Chemistry Letters

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Cd2+ coordination: an efficient structuring switch for polypeptide polymers

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