Rhodium(iii)/amine synergistically catalyzed enantioselective Michael addition of cyclic ketones with α,β-unsaturated 2-acyl imidazoles
文献信息
Yu Du, Qiang Kang
An enantioselective Michael addition of α,β-unsaturated 2-acyl imidazoles with cyclic ketones catalyzed synergistically by a chiral-at-metal Rh(III) complex and a secondary amine has been developed, affording the corresponding adducts with up to 98% yield and 99% ee. The diastereomeric ratios are in the range from 2 : 1 to 10 : 1. In these reactions, the combination of a chiral-at-metal complex and a secondary amine catalyst activates an electrophile and nucleophile separately.
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来源期刊
Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry













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