A rhodol-hemicyanine based ratiometric fluorescent probe for real-time monitoring of glutathione dynamics in living cells
文献信息
Minghao Ren, Linfang Wang, Xin Lv, Yuanqiang Sun, Hu Chen, Keyuan Zhang, Qi Wu, Yurong Bai, Wei Guo
Glutathione (GSH) plays crucial roles in various physiological and pathological processes. The fluctuation of the GSH level is closely associated with a variety of diseases and cellular functions. Hence, it is important to real-time monitor the fluctuation of GSH in living cells. In this work, we presented a rhodol-hybridized hemicyanine fluorophore (RdH) as a selective, rapid-response, ratiometric, and reversible fluorescent probe for intracellular GSH (t1/2 = 89 ms, Kd = 1.42 mM). The imaging assays in living cells revealed that RdH could be used to real-time monitor GSH dynamics in A549 cells under a laser scanning confocal microscope by ratiometric fluorescence changes.
期刊推荐

Journal of Saudi Chemical Society

Organic Process Research & Development

Chemical Communications

Drug Discovery Today

Chemistry Education Research and Practice

Russian Journal of Bioorganic Chemistry

Journal of Natural Medicines

Acta Materialia

Russian Journal of Organic Chemistry

Current Opinion in Solid State & Materials Science
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