Domino synthesis of fully substituted pyridines by silver-catalyzed chemoselective hetero-dimerization of isocyanides

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发布日期 2019-12-23

DOI 10.1039/C9QO01333D

影响因子 5.281

作者

Zhongyan Hu, Mingyue Zhang, Qinghua Zhou, Xianxiu Xu, Bo Tang

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摘要

A silver-catalyzed hetero-dimerization of various vinyl isocyanides with isocyanoacetamides has been developed. This multistep domino reaction provides a facile protocol for the expedient synthesis of fully substituted pyridines in a single operation from readily available starting materials. An amidoketenimine and an azabutadienylketene are proposed as the key intermediates involved in this domino transformation. In addition, the resulting polysubstituted pyridines can be conveniently converted to pyridine-fused polycyclic frameworks.

期刊推荐

Bio-Medical Materials and Engineering

Computational Materials Science

Synlett

Diamond and Related Materials

Advances in Cement Research

Advanced Composite Materials

Construction and Building Materials

Advanced Powder Technology

Journal of Computer-Aided Molecular Design

Composite Interfaces

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Domino synthesis of fully substituted pyridines by silver-catalyzed chemoselective hetero-dimerization of isocyanides

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来源期刊

Organic Chemistry Frontiers

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