Divergent synthesis of unsymmetrical azobenzenes via Cu-catalyzed C–N coupling

文献信息

发布日期 2021-08-14

DOI 10.1039/D1QO00945A

影响因子 5.281

作者

Yuzhou Wang, Rongrong Xie, Lingyu Huang, Ya-Nan Tian, Shihai Lv, Xiangfei Kong, Shiqing Li

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摘要

An efficient, one-pot, and low-cost metal-catalyzed tandem Chan–Lam coupling/deprotection/oxidation reaction to access unsymmetrical azobenzenes was developed. The phthaloyl group was automatically released from the rest of the molecule under the conditions of the basic catalytic system of this protocol, without extra steps for deprotection. A variety of azobenzenes were easily obtained using this C–N coupling strategy, without precautions against generating undesired azo by-products. Moreover, an unusual, three-component and domino Ullmann/Chan–Lam/deprotection/oxidation reaction proceeded smoothly to assemble azobenzenes in good yields, where phthalic hydrazide served as a source of N2.

期刊推荐

Accounts of Chemical Research

Chemistry of Heterocyclic Compounds

Analyst

Cement and Concrete Research

Biopolymers

Australian Journal of Chemistry

Journal of the American Chemical Society

Chemical & Pharmaceutical Bulletin

AIAA Journal

Bulletin of the Chemical Society of Japan

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Divergent synthesis of unsymmetrical azobenzenes via Cu-catalyzed C–N coupling

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