Multifunctional DNA nanoprobe for tumor-targeted synergistic therapy by integrating chemodynamic therapy with gene silencing

文献信息

发布日期 2023-05-29
DOI 10.1039/D2NH00575A
影响因子 10.989
作者

Qiaorong Tang, Qianqian Li, Lu Shi, Wei Liu, Baoxin Li, Yan Jin


查看原文

摘要

Due to the high complexity, diversity and heterogeneity of tumor occurrence and development, multi-mode synergistic therapy is more effective than single treatment modes to improve the antitumor efficacy. Also, multifunctional probes are crucial to realize synergistic therapy. Herein, a multifunctional DNA tetrahedron nanoprobe was ingeniously designed to simultaneously achieve chemodynamic therapy (CDT) and gene silencing for synergistic antitumor. The multifunctional DNA tetrahedron nanoprobe, DNA tetrahedron-silver nanocluster-antagomir-21 (D-sgc8-DTNS-AgNCs-Anta-21), integrated a CDT reagent (DNA-AgNCs) and miRNA-21 inhibitor (Anta-21) with a specific recognition probe (aptamer). After targeted entry in cancer cells, D-sgc8-DTNS-AgNCs-Anta-21 silenced endogenous miRNA-21 by Anta-21 and produced highly toxic ˙OH by reacting with H2O2, which induced apoptosis in the tumor cells. The targeted recognition of aptamers led to the concentration-dependent death of HeLa cells. On the contrary, the cell survival rate of normal cells was basically unaffected with an increase in the concentration of D-sgc8-DTNS-AgNCs-Anta-21. Therefore, the diverse functions, biocompatibility and programmability of DNA provide a useful and easy way to assemble multifunctional probes for synergistic therapy.

相关文献

Bimodal crystallization at polymer–fullerene interfaces

Dyfrig Môn, Anthony M. Higgins, David James, Mark Hampton, J. Emyr Macdonald, Michael B. Ward, Philipp Gutfreund, Samuele Lilliu, Jonathan Rawle

2014-11-26 Paper

DOI: 10.1039/C4CP04253K

In situ non-aqueous nucleation and growth of next generation rare-earth-free permanent magnets

Aoran Xu, George E. Sterbinsky, Dario A. Arena, Ziying Wang, Peter W. Stephens

2014-11-21 Paper

DOI: 10.1039/C4CP04451G

A novel two-dimensional MgB6 crystal: metal-layer stabilized boron kagome lattice

Sheng-Yi Xie, Xian-Bin Li, Nian-Ke Chen, Yeliang Wang, Shengbai Zhang, Hong-Bo Sun

2014-11-07 Paper

DOI: 10.1039/C4CP03728F

Near field plasmonic gradient effects on high vacuum tip-enhanced Raman spectroscopy

Mengtao Sun

2014-11-07 Perspective

DOI: 10.1039/C4CP03871A

Electronic structures at the interface between Au and CH3NH3PbI3

Xiaoliang Liu, Chenggong Wang, Lu Lyu, Congcong Wang, Zhengguo Xiao, Cheng Bi, Jinsong Huang, Yongli Gao

2014-11-07 Paper

DOI: 10.1039/C4CP03842H

Formation of dibenzofuran, dibenzo-p-dioxin and their hydroxylated derivatives from catechol

Mohammednoor Altarawneh, Bogdan Z. Dlugogorski

2014-11-21 Paper

DOI: 10.1039/C4CP04168B

Structure of palladium nanoparticles under oxidative conditions

Cristina Popa, Tianwei Zhu, Ionut Tranca, Payam Kaghazchi, Emiel J. M. Hensen

2014-12-08 Paper

DOI: 10.1039/C4CP01761G

Contents list

Front/Back Matter

DOI: 10.1039/C4CP90180K

“Tschitschibabin type biradicals”: benzenoid or quinoid?

Prince Ravat, Martin Baumgarten

2014-11-11 Paper

DOI: 10.1039/C4CP03522D

您可能还喜欢

化合物问答

4-[4-三氟甲基苯基]恶唑(CAS号:1126636-40-5)通常如何合成?

4-[4-三氟甲基苯基]恶唑通常通过将4-三氟甲基苯酚与异硫氰酸苯酯在有机溶剂中进行酯化反应合成。该反应可在无水条件下,使用适当的催化剂,如四丁基氢氧化铵,以提...

1126636-40-54-(4-(Trifluoromethy...
化合物问答

氢溴酸西酞普兰(CAS号:59729-32-7)的主要用途是什么?

氢溴酸西酞普兰主要用于治疗抑郁症,通过调节大脑中的神经递质平衡来改善情绪。

59729-32-71-[3-(Dimethylamino)...
化合物问答

RockPhos Pd G3(CAS号:2009020-38-4)通常如何合成?

RockPhos Pd G3 通常通过钯催化偶联反应合成,使用配体 (2'-Amino-2-biphenylyl)(methanesulfonato-kappa...

2009020-38-4(2'-Amino-2-biphenyl...
化合物问答

1-哌啶甲酰胺(CAS号:2158-03-4)的市场或研究趋势如何?

1-哌啶甲酰胺作为有机合成中的重要中间体,其市场需求主要受医药、农药、染料等行业推动。近年来,随着新药开发和绿色化学的发展,该化合物的研究趋势集中在开发更高效、...

2158-03-41-Piperidinecarboxam...
化合物问答

2-(二苯基膦基)乙胺(CAS号:4848-43-5)适用哪些法规指南?

2-(二苯基膦基)乙胺适用于多种法规指南,包括但不限于《全球化学品统一分类和标签制度》(GHS),欧盟《化学品注册、评估、授权和限制》法规(REACH),以及美...

4848-43-52-(Diphenylphosphino...
化合物问答

如何储存间苯二甲酸二烯丙酯(CAS号:1087-21-4)?

间苯二甲酸二烯丙酯应储存在阴凉、干燥、通风良好的地方,远离火源和热源。储存容器应密封,避免光照和高温。储存温度应控制在25℃以下,相对湿度应低于80%。避免与其...

1087-21-4Diallyl isophthalate
化合物问答

什么是间甲苯异硫代异氰酸酯(CAS号:621-30-7)?

间甲苯异硫代异氰酸酯是一种有机化合物,分子式为C7H7NO2S,具有刺激性气味。它是一种重要的有机合成中间体,在合成其他化合物时广泛应用。

621-30-71-Isothiocyanato-3-m...
化合物问答

在合成中是否有N-Boc-D-苯丙氨醇(CAS号:106454-69-7)的替代品?

在合成中,可以考虑使用N-Cbz-D-苯丙氨醇或N-Fmoc-D-苯丙氨醇作为替代品。这些化合物同样具有保护氨基的功能,且在合成过程中表现出良好的反应性能。

106454-69-72-Methyl-2-propanyl ...
化合物问答

3-羟甲基-2-氧异丙基吡啶(CAS号:954240-50-7)的主要用途是什么?

3-羟甲基-2-氧异丙基吡啶主要用于有机合成领域,可以作为合成其他药物、农药或精细化学品的中间体。此外,它还可能在实验室研究中作为特定反应的前体或溶剂。

954240-50-7(2-Isopropoxy-3-pyri...
化合物问答

6-氨基-9-甲基嘌呤(CAS号:700-00-5)应用于哪些行业?

6-氨基-9-甲基嘌呤目前主要应用于医药行业,作为某些药物的中间体。此外,它还可能用于聚合物、传感器和半导体的某些领域,作为功能性单体或掺杂剂。

700-00-59-Methyl-9H-purin-6-...

来源期刊

Nanoscale Horizons

Nanoscale Horizons
CiteScore: 16.3
自引率: 3.4%
年发文量: 138

Nanoscale Horizons is a leading journal for the publication of exceptionally high-quality, innovative nanoscience and nanotechnology. The journal places an emphasis on original research that demonstrates a new concept or a new way of thinking (a conceptual advance), rather than primarily reporting technological improvements. However, outstanding articles featuring truly breakthrough developments such as record performance alone may also be published in the journal. For work to be published it must be of significant general interest to our community-spanning readership. Topics covered in the journal include, but are not limited to: Synthesis of nanostructured and nanoscale materials Quantum materials 2D materials Layered materials Layered quantum materials Characterisation of functional nanoscale materials and bio-assemblies Properties of nanoscale materials Self-assembly and molecular organisation Complex hybrid nanostructures Nanocomposites, nanoparticles, nanocrystalline materials, and nanoclusters Nanotubes, molecular nanowires and nanocrystals Molecular nanoscience Nanocatalysis Theoretical modelling Single-molecules Plasmonics Nanoelectronics and molecular electronics Nanophotonics Nanochips, nanosensors, nanofluidics and nanofabrication Carbon-based nanoscale materials and devices Biomimetic materials Nanobiotechnology/bionanomaterials Nanomedicine Regulatory approaches and risk assessment

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。