Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates
文献信息
发布日期
2022-08-03
DOI
10.1039/D2SC02665A
影响因子
9.825
作者
Youcan Zhang
查看原文
摘要
The introduction of fluorine atoms into organic molecules is an attractive but challenging topic. In this work, an interesting palladium-catalyzed difluoroalkylative carbonylation of aryl olefins has been developed. A wide range of aryl olefins were transformed into the corresponding difluoropentanedioate compounds with good functional-group tolerance and excellent regioselectivity. Inexpensive ethyl bromodifluoroacetate acts both as a difluoroalkyl precursor and a nucleophile here. Additionally, a scale–up reaction was also performed successfully, and further transformations of the obtained product were shown as well.
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来源期刊
Chemical Science
CiteScore:
14.4
自引率:
3.9%
年发文量:
1413
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