Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels

文献信息

发布日期 2023-11-29
DOI 10.1039/D3BM01783D
影响因子 6.843
作者

Zuolong Liu, Xianchi Zhou, Yongcheng Chen, Yanwen Ni, Zihao Zhu, Wenzhong Cao, Kexin Chen, Yu Yan


查看原文

摘要

Foreign body response (FBR) represents an immune-mediated cascade reaction capable of inducing the rejection of foreign implants, thereby compromising their in vivo performance. Pure zwitterionic hydrogels have demonstrated the ability to resist long-term FBR, owing to their outstanding antifouling capabilities. However, achieving such a robust anti-FBR effect necessitates stringent requirements concerning the purity of zwitterionic materials, which constrains their broader functional applications. Herein, we present a biocompatible, controllably degradable, and functionalizable zwitterion-albumin hybrid hydrogel. The zwitterionic hydrogel crosslinked with serum albumin exhibits controllable degradation and excels in preventing the adsorption of various proteins and adhesion of cells and bacteria. Moreover, the hydrogel significantly alleviates the host's FBR compared with PEG hydrogels and particularly outperforms PEG-based cross-linker crosslinked zwitterionic hydrogels in reducing collagen encapsulation when subcutaneously implanted into mice. The zwitterion-albumin hybrid hydrogel shows potential as a functionalizable anti-FBR material in the context of implantable materials and biomedical devices.

相关文献

Understanding the differences between iron and palladium in cross-coupling reactions

Xiaobo Sun, Trevor A. Hamlin

2019-02-25 Paper

DOI: 10.1039/C8CP07671E

Elucidating the morphological aspects and proton dynamics in a hybrid perfluorosulfonic acid membrane for medium-temperature fuel cell applications

Saeed Akbari, Mohammad Taghi Hamed Mosavian, Fatemeh Moosavi, Ali Ahmadpour

2018-11-05 Paper

DOI: 10.1039/C8CP05377D

Inside front cover

Cover

DOI: 10.1039/C9CP90110H

Quantum-classical dynamics of the capture of neon atoms by superfluid helium nanodroplets

Miquel Blancafort-Jorquera, Arnau Vilà, Miguel González

2018-11-06 Paper

DOI: 10.1039/C8CP05140B

Back cover

Cover

DOI: 10.1039/C8CP91850C

Front cover

Cover

DOI: 10.1039/C9CP90109D

Effects of hydrogen bonding on the gas-phase reactivity of didehydroisoquinolinium cation isomers

Nelson R. Vinueza, Bartłomiej J. Jankiewicz, Vanessa A. Gallardo, John J. Nash, Hilkka I. Kenttämaa

2018-08-02 Paper

DOI: 10.1039/C8CP03350A

Defect generation in TiO2 nanotube anodes via heat treatment in various atmospheres for lithium-ion batteries

Andreas I. Savva, Kassiopeia A. Smith, Matthew Lawson, Sterling R. Croft, Ariel E. Weltner, Chris D. Jones, Hailey Bull, Paul J. Simmonds, Lan Li, Hui Xiong

2018-08-16 Paper

DOI: 10.1039/C8CP04368J

您可能还喜欢

化合物问答

如何储存1,2-环己二酮环乙缩醛(CAS号:4746-96-7)?

1,2-环己二酮环乙缩醛应储存在阴凉、干燥、通风良好的地方,避免阳光直射。建议使用密封容器保存,并保持环境温度在室温范围内,远离火源和热源。

4746-96-71,4-Dioxaspiro[4.5]d...
化合物问答

Ecopladib(CAS号:381683-92-7)的市场或研究趋势如何?

Ecopladib作为一种新型的药物,主要应用于治疗高胆固醇等疾病。目前,市场和研究趋势显示,Ecopladib因其独特的药理作用而受到关注。随着对心血管疾病治...

381683-92-7Ecopladib
化合物问答

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine(CAS号:52538-09-7)通常如何合成?

2,3-二甲基-3H-咪唑[4,5-c]吡啶通常通过咪唑和2,3-二甲基吡啶的缩合反应合成。具体来说,将咪唑和2,3-二甲基吡啶在适当的溶剂中进行加热或加压反应...

52538-09-72,3-Dimethyl-3H-imid...
化合物问答

2,3,4,5-tetrahydro-1H-3-苯并氮杂环;盐酸盐(CAS号:17379-01-0)的市场或研究趋势如何?

该化合物在药物化学和有机合成中有一定的应用。近年来,随着对新型药物化合物的需求增加,该化合物的研究趋势主要集中在探索其生物活性,尤其是其在神经系统疾病治疗中的潜...

17379-01-02,3,4,5-Tetrahydro-1...
化合物问答

解草嗪(CAS号:68-90-6)安全吗?

解草嗪具有一定的化学毒性,因此在操作过程中需要采取适当的防护措施。应避免吸入、皮肤接触和眼睛接触。处理时应佩戴化学防护手套、实验服和护目镜。

68-90-6(2-Ethyl-1-benzofura...
化合物问答

如何储存盐酸甘氨酸丁酯(CAS号:13048-99-2)?

盐酸甘氨酸丁酯应储存在阴凉、干燥、通风良好的地方,避免阳光直射和高温环境,温度应控制在25℃以下。储存容器应密封,避免与空气中的水分和酸性物质接触,以防发生水解...

13048-99-2Butyl glycinate hydr...
化合物问答

什么是2-Iodo-N,N-dimethylbenzamide(CAS号:54616-46-5)?

2-碘-N,N-二甲基苯胺是一种有机化合物,化学名为2-Iodo-N,N-dimethylbenzamide。其分子式为C<sub>9</sub>H<sub>1...

54616-46-52-Iodo-N,N-dimethylb...
化合物问答

如何储存2-氨基-N-环己基乙酰胺(CAS号:16817-90-6)?

应储存于阴凉、干燥、通风良好的地方,避免高湿度和光照,最好存放在密封容器中。

16817-90-6N-Cyclohexylglycinam...
化合物问答

5-溴-2-(4H-1,2,4-三唑-4-基)吡啶(CAS号:959240-99-4)的市场或研究趋势如何?

随着医药、农药和新材料领域的发展,该化合物作为关键中间体的应用日益增多。特别是在药物合成中,由于其独特的化学性质,可以用于合成多种药物分子。未来的研究趋势可能集...

959240-99-45-Bromo-2-(4H-1,2,4-...
化合物问答

2,4-二溴-6-三氟甲基嘧啶(CAS号:785778-00-9)通常如何合成?

2,4-二溴-6-三氟甲基嘧啶通常通过溴化反应合成。首先,将6-三氟甲基嘧啶与溴化剂(如液溴)在适当的溶剂(如二氯甲烷、四氢呋喃)中反应,加入适当的催化剂(如四...

785778-00-92,4-Dibromo-6-(trifl...

来源期刊

Biomaterials Science

Biomaterials Science
CiteScore: 11.5
自引率: 3.4%
年发文量: 492

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。