Inducing and monitoring mitochondrial pH changes with an iridium(iii) complex via two-photon lifetime imaging

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发布日期 2023-10-05

DOI 10.1039/D3DT02541A

影响因子 4.39

作者

Meng Hu, Xin-Lan Zhou, Tian-Xin Xiao, Liang Hao, Yi Li

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摘要

Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(III) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.

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来源期刊

Dalton Transactions

CiteScore: 6.6

自引率: 11.4%

年发文量: 1868

Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant. Specific guidance for some areas of our scope is given below.

Inducing and monitoring mitochondrial pH changes with an iridium(iii) complex via two-photon lifetime imaging

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