Transition metal free C(sp3)–C(sp3) coupling between alcohols and N-heteroarenes via a dehydrogenative SET/HAT process

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发布日期 2023-12-12

DOI 10.1039/D3QO01875J

影响因子 5.281

作者

Xiaoping Liu, Dongjie Wang, Jordan Garo, Jean-Marc Sotiropoulos, Marc Taillefer

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摘要

Transition metal free direct activation and Csp3–Csp3 coupling of benzylic alcohol derivatives with N-heteroarenes was performed in a basic medium in the presence of an aryl halide additive. Various E-alkenyl heteroarenes were obtained, among which is the STB-8 imaging reagent of β-amyloid associated with Alzheimer's disease. From the combination of experimental results and DFT calculations, we assume that the reaction proceeds via a combined SET/HAT dehydrogenation pathway.

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来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Transition metal free C(sp3)–C(sp3) coupling between alcohols and N-heteroarenes via a dehydrogenative SET/HAT process

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