Access to pyrrolines and fused diaziridines by selective radical addition to homoallylic diazirines‡
文献信息
发布日期
2023-12-29
DOI
10.1039/D3SC04886A
影响因子
9.825
作者
Zhigang Ma, Xinxin Wu, Haotian Li, Zhu Cao
查看原文
摘要
Pyrroline derivatives are common in bioactive natural products and therapeutic agents. We report here a synthesis of pyrrolines and fused diaziridines by divergent radical cyclization of homoallylic diazirines, which can serve as an internal radical trap and a nitrogen source. This reaction proceeds by selective radical addition to CC or NN bonds followed by intramolecular cyclization. Frontier molecular orbital analysis provides a deep insight into the origin of the selectivity. The reaction demonstrates a new cyclization mode, broad functional group compatibility and high product diversity, and reveals a much broader chemical space for diazirine studies.
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来源期刊
Chemical Science
CiteScore:
14.4
自引率:
3.9%
年发文量:
1413
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