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N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide(CAS: 871700-17-3)
![N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide](https://cnstatic.chemtradehub.com/structs/871/871700-17-3-74f2.webp "N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide")
CAS号
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其他供应商提供的 N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
![N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — 上海颖心实验室设备有限公司](https://cnstatic.chemtradehub.com/suppliers/67cdd97a57537e5c8069adfb/67cdd97a57537e5c8069adfb-logo.webp){kind=logo}
![N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — 北京百灵威科技有限公司](https://cnstatic.chemtradehub.com/suppliers/67cde31e57537e5c8069aebf/67cde31e57537e5c8069aebf-logo.webp){kind=logo}
![N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — 湖北达豪化工有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce362d57537e5c8069b51b/67ce362d57537e5c8069b51b-logo.webp){kind=logo}
基本信息
分子式
C26H23FIN5O4
分子量
615.4 g/mol
Physical Properties
密度
1.74
化学标识符
SMILES
CC(=O)Nc1cccc(c1)n2c(=O)n(C3CC3)c(=O)c4c(Nc5ccc(I)cc5F)n(C)c(=O)c(C)c24
InChIKey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N
数据库引用
MDL号
MFCD17215075
常见问题
曲美替尼游离碱是一种吡啶并嘧啶类化合物，化学结构包含3-环丙基、6,8-二甲基及氟碘苯基氨基取代基。其分子式为C23H23FN6O4，属于多靶点酪氨酸激酶抑制剂，常用于癌症治疗研究。该化合物在药物化学中作为活性成分，具有特定的生物活性和药理特性，是曲美替尼药物制剂的前体形式。
曲美替尼游离碱主要用于抗肿瘤治疗，特别是针对MET和ROS1基因突变的非小细胞肺癌（NSCLC）。作为激酶抑制剂，它通过阻断异常信号传导路径，抑制癌细胞增殖。该化合物在临床前研究中显示对多种实体瘤的治疗潜力，是开发靶向治疗药物的重要中间体。
曲美替尼游离碱作为药物前体，需严格遵循药品安全规范。其安全性取决于具体应用场景，通常具有一定的细胞毒性和代谢产物潜在风险。操作时应佩戴防护手套、护目镜，避免吸入粉尘。储存和使用过程中需注意防潮、避光，确保在受控环境下进行。
曲美替尼游离碱应密封保存于阴凉干燥处，避免光照和潮湿环境。推荐储存温度为2-8℃，并置于氮气保护容器中以防止氧化。需远离热源和不相容物质，如强酸、强碱。储存期限需根据具体产品说明，通常建议在避光、低温条件下短期保存。
安全须知
使用前请验证产品规格和安全数据。联系供应商获取详细安全信息。
请始终遵循正确的操作程序
