化合物问答
盐酸乐卡地平(CAS号：132866-11-6)通常如何合成？
答案
![3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, hydrochloride (1:1)](https://cnstatic.chemtradehub.com/structs/132/132866-11-6-9c51.webp "3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, hydrochloride (1:1)")
盐酸乐卡地平通常通过多步合成反应制备。首先，合成中间体1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3-[(2-[(3,3-二苯基丙基)甲基氨基]-1,1-二甲基乙基]甲基酯。在此过程中，会使用到催化剂如铜盐或钯盐，经过酯化反应、还原、取代等步骤，最终得到目标产物。
关于
CAS号
132866-11-6
英文名称
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, hydrochloride (1:1)
中文名称
盐酸乐卡地平
分子式
C36H42ClN3O6
分子量
648.2 g/mol
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
InChIKey
WMFYOYKPJLRMJI-UHFFFAOYSA-N
最后更新: 2025-09-07 10:18
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