化合物问答
1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride(CAS号：1628047-87-9)通常如何合成？
答案
![Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2)](https://cnstatic.chemtradehub.com/structs/162/1628047-87-9-6bcd.webp "Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2)")
该化合物通常通过1-哌嗪基甲基-4'-氯-5,5-二甲基-3,4,5,6-四氢双环[1.1.0]苯与相应的二醇或醇在碱性条件下进行缩合反应，生成环己烯基甲基哌嗪，然后通过氯化反应得到最终产物。常见的催化剂包括四丁基氢氧化铵等。产率约为60%-70%。
关于
CAS号
1628047-87-9
英文名称
Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2)
中文名称
1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
分子式
C19H29Cl3N2
分子量
391.81 g/mol
SMILES
Clc1ccc(cc1)C1=C(CCC(C1)(C)C)CN1CCNCC1.Cl.Cl
InChIKey
KISZDCHFJKYNFW-UHFFFAOYSA-N
最后更新: 2025-09-19 21:14
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