化合物问答
糠酸氟替卡松-D5(CAS号：397864-44-7)通常如何合成？
答案
![(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate](https://cnstatic.chemtradehub.com/structs/397/397864-44-7-6c02.webp "(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate")
糠酸氟替卡松-D5通常通过甾体激素的合成路径，使用氯甲酸乙酯和氟化钠进行氟化反应，随后进行酯化反应制备得到。该过程通常需要使用有机溶剂，如二氯甲烷或乙醚，并在适当的温度下进行，产率可达80%以上。
关于
CAS号
397864-44-7
英文名称
(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate
中文名称
糠酸氟替卡松-D5
分子式
C27H29F3O6S
分子量
538.58 g/mol
SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
InChIKey
XTULMSXFIHGYFS-VLSRWLAYSA-N
最后更新: 2025-09-25 13:48
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![(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate — 湖北万得化工有限公司](https://cnstatic.chemtradehub.com/suppliers/67cecc352b2de6e8e95a5c3a/67cecc352b2de6e8e95a5c3a-logo.webp){kind=logo}
![(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate — 湖北达豪化工有限公司](https://cnstatic.chemtradehub.com/suppliers/67ce362d57537e5c8069b51b/67ce362d57537e5c8069b51b-logo.webp){kind=logo}
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