化合物问答
(R)-N-Boc-2-甲酸哌啶(CAS号：28697-17-8)通常如何合成？
答案
![(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid](https://cnstatic.chemtradehub.com/structs/286/28697-17-8-315f.webp "(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid")
(R)-N-Boc-2-甲酸哌啶通常通过氨解法合成，首先将2-甲基-2-丙醇与三氯乙酸反应生成相应的酯，然后与哌啶反应，通过一锅法或分步法将哌啶的伯胺基转化为叔胺基，生成目标化合物。常用的催化剂有三乙胺等，最终产物的产率可达80%-90%。
关于
CAS号
28697-17-8
英文名称
(2R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperidinecarboxylic acid
中文名称
(R)-N-Boc-2-甲酸哌啶
分子式
C11H19NO4
分子量
229.28 g/mol
SMILES
CC(C)(C)OC(=O)N1CCCCC1C(=O)O
InChIKey
JQAOHGMPAAWWQO-MRVPVSSYSA-N
最后更新: 2025-09-29 09:43
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