化合物问答
Mc-Val-Cit-PABC-PNP(CAS号：159857-81-5)通常如何合成？
答案
![N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N~5~-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide](https://cnstatic.chemtradehub.com/structs/159/159857-81-5-872c.webp "N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N~5~-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide")
Mc-Val-Cit-PABC-PNP 通常通过多步合成完成。首先，合成N-[6-(2,5-二酮基-1H-吡咯-1-基)己酰基]-L-缬氨酸，然后通过缩合反应与N-[(4-[(2-氨基乙酰氧基)甲基]苯基]羰基]鸟氨酸酰胺反应得到目标化合物。该合成过程中通常使用碱性催化剂，产率约为80%左右。
关于
CAS号
159857-81-5
英文名称
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N~5~-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
中文名称
Mc-Val-Cit-PABC-PNP
分子式
C35H43N7O11
分子量
737.7562 g/mol
SMILES
CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)Nc1ccc(cc1)COC(=O)Oc2ccc(cc2)[N+](=O)[O-])NC(=O)CCCCCN3C(=O)C=CC3=O
InChIKey
HYSPJPGXSALJRR-DHIFEGFHSA-N
最后更新: 2025-10-01 21:42
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